Module 8:  Long-Term Memory

Long-term memory is a type of memory responsible for storing information over extended periods, ranging from days to a lifetime. It is divided into two main types: declarative (explicit) and non-declarative (implicit) memory. Each type involves different brain regions and serves distinct functions.

Declarative memory involves conscious recall of facts and events. It is further divided into two subtypes:

Episodic memory is the ability to recall personal experiences and specific events, including the context in which they occurred (time, place, emotions).

Example: Remembering your last birthday party or your first day at school.

Brain Regions: The hippocampus, medial temporal lobe, and prefrontal cortex are critical for episodic memory.

Semantic memory involves the storage of general knowledge about the world, including facts, concepts, and meanings.

Example: Knowing that Paris is the capital of France or that a zebra is an animal with black and white stripes.

Brain Regions: The hippocampus, lateral and anterior temporal cortex, and parts of the prefrontal cortex are involved in semantic memory. 

Non-declarative memory involves unconscious recall and is associated with learning and memory that are expressed through performance rather than conscious recollection. It includes several subtypes: 

Procedural memory is the memory of how to perform tasks and actions, often developed through repetition and practice.

Example: Riding a bicycle, playing a musical instrument, or typing on a keyboard.

Brain Regions: The basal ganglia, cerebellum, and motor cortex play significant roles in procedural memory.

Classical Conditioning involves learning through association, where a neutral stimulus becomes associated with a meaningful stimulus, eliciting a conditioned response.

Example: A dog salivating when it hears a bell if the bell has been repeatedly associated with food.

Brain Regions: The cerebellum is crucial for classical conditioning, especially for the conditioned responses related to reflexes. 

Priming is the unconscious improvement in performance or ability to identify or process a stimulus due to prior exposure to that stimulus.

Example: Faster recognition of the word "nurse" if previously exposed to the word "doctor."

Brain Regions: Various regions of the neocortex are involved in priming, depending on the type of priming.

Non-Associative Learning involves habituation (decreased response to a repeated stimulus) and sensitization (increased response to a stimulus following exposure to a strong stimulus).

Example: Becoming less startled by a loud noise over time (habituation) or becoming more sensitive to pain after a severe injury (sensitization).

Brain Regions: Reflex pathways, including the spinal cord and brainstem, are involved in non-associative learning. 

Summary

Declarative (Explicit) Memory: Conscious recall of facts and events.

Episodic Memory: Personal experiences (hippocampus, medial temporal lobe, prefrontal cortex).

Semantic Memory: General knowledge (hippocampus, temporal cortex, prefrontal cortex).

Non-Declarative (Implicit) Memory: Unconscious recall and performance.

Procedural Memory: Skills and tasks (basal ganglia, cerebellum, motor cortex).

Classical Conditioning: Learning through association (cerebellum).

Priming: Improved processing due to prior exposure (neocortex).

Non-Associative Learning: Habituation and sensitization (reflex pathways, spinal cord, brainstem).